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  • Many clinical procedures utilize ablation to target abnormal tissues. For instance, pulmonary vein isolation is a procedure that uses radiofrequency ablation (RFA) to treat atrial fibrillation. Renal denervation uses RFA to burn the nerves in the renal arteries to treat resistant hypertension. Many cancers are also treated with RFA, such as hepatocellular carcinoma.

  • One problem with procedures using RFA is they lack the ability to monitor lesion formation and provide functional information in real-time.

  • The theranostic endoscopic system combines three medical modalities into one device. By utilizing ultrasound imaging, photoacoustic imaging, and laser-based ablation, the device can ablate tissue and simultaneously monitor lesion formation, temperature, and distinguish tissue types.


  1. M. Basij, S. John, D. Bustamante, L. Kabbani, W. Maskoun, and M. Mehrmohammadi, "Integrated Ultrasound and Photoacoustic-guided Laser Ablation Theranostic Endoscopic System," IEEE Transactions on Biomedical Engineering, 2022.

  2. M. Basij, S. John, D. Bustamante, L. Kabbani, and M. Mehrmohammadi, "Development of an Integrated Photoacoustic-Guided Laser Ablation Intracardiac Theranostic System," in 2021 IEEE International Ultrasonics Symposium (IUS), 2021: IEEE, pp. 1-4.

  3. M. B. Mohammad Mehrmohammadi, Samuel John, "Endoscopic array-based photoacoustic-guided laser ablation Theranostic System," Disclosure filed in August 2021.

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